New research results may help in better treatment of ‘Type-2’ Diabetes!

New Delhi: Scientists have found genetic similarities and differences between different forms of ‘type-2’ diabetes in India and Europe, which they say can be used to further improve treatment of the disease in the country. Researchers in Sweden previously demonstrated that diabetes can be divided into 5 subgroups and that there are genetic differences between the 4 subgroups associated with ‘type-2’ diabetes. The new study, published in the journal The Lancet Regional Health-Southeast Asia, confirms that the classification system applies to a group in western India. “The study highlights genetic similarities and differences between different forms of type 2 diabetes in India and Europe,” said Rashmi Prasad, assistant professor of genomics, diabetes and endocrinology at Lund University in Sweden. “We see this as an encouraging new step toward better understanding the rise in type 2 diabetes in India,” Prasad said in a statement. The results are based on clinical data from 2,217 patients and a study of 821 people with type 2 diabetes in western India.

Vitamin B12 deficiency
According to the study, the second largest group in India is patients with obesity-associated diabetes (MOD). The Indian participants included in this cohort were associated with genetic variants for vitamin B12 deficiency and this was not observed in the Swedish population. ‘In our study, this is an interesting example of genetic differences between the Indian and Swedish groups,’ Prasad said. These results suggest that the causes of the disease are different in the populations of the two regions. Vitamin B12 deficiency may be a factor in the disease in the Indian MOD group.’

Being undernourished at a young age, a major reason for early onset of type-2 diabetes!
Rashmi Prasad said, “We were able to confirm our earlier findings that a specific form of type-2 diabetes was found in people with a relatively low ‘body mass index’ and is the most common form of diabetes in India.” Normal type.’ This subgroup is known as patients with severe insulin-deficient diabetes, and this is a form of type-2 diabetes, the researchers said. “Being undernourished at a young age in Indians may be a major factor in the early onset of type 2 diabetes, and this may be the reason why we are seeing this difference between patients in Sweden and India,” Prasad said. Our research also found that prevention of undernutrition in Indians can also prevent the spread of type-2 diabetes.’