Monkeypox virus affects human brain cells
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A study has shown that the monkeypox virus can affect cells responsible for normal brain functioning, causing neurological symptoms in people. The mpox virus is spread primarily through close physical contact and causes an illness with symptoms similar to smallpox, although it is less severe.
May of 2022 saw a large outbreak of the virus, which spread to more than 100 countries and caused more than 86,900 infections worldwide. Between January 1, 2022, and November 30, 2023, a total of 92,783 laboratory-confirmed cases of mpox, including 171 deaths, have been reported to the World Health Organization (WHO) from 116 countries. Researchers at the University of Alberta used a laboratory experiment to infect human brain cells with the Mpox virus.
In newly published research in the journal Proceedings of the National Academy of Sciences, the team found that the Mpox virus is affecting astrocytes, a type of cell responsible for the normal functioning of the brain, triggering an excessive immune response. . ‘Astrocytes are the most abundant nerve cells in the brain,’ said study author Hajar Miranzadeh Mahabadi, who is a postdoctoral fellow in medicine at the university. ‘We found that monkeypox virus can efficiently infect these cells and induce a type of brain cell death we call pyroptosis.’ The virus is spread by skin or sexual contact or respiratory droplets. This outbreak has primarily affected men who have sex with men.
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